The p53 tumor suppressor gene is altered in a variety of human cancers and mutated p53 protein was found to induce anti-p53 antibodies in sera of patients with various types of malignant neoplastic disease.
We report here the presence of anti-p53 antibodies in sera from patients with various disorders as well as from healthy controls by enzyme-linked immunosorbent assay.
The prevalence of anti-p53 antibodies in cancer was higher than neoplastic disease.
High antibody concentrations were found in patients with 1 pharyngeal, 3 esophageal, 4 lung, 4 gastric, 1 pancreatic, 3 colonic and 4 ovarian cancer.
Serological analysis does not require biopsy of the tumor.
Therefore, determination of anti-p53 antibodies can be used for tumor screening and for early diagnosis.
[Rinsho Byori 50 : 90`92, 2002 ]
*Department of Clinical Laboratory, Kyoto National Hospital, Kyoto 612-8555
σt2001N629ϊEσ2001N1213ϊ
*§sa@Υ°ΈΘ(§612-8555 ss©ζ[ό¨¬1-1)
E-mail :hsakai@kyotolan.hosp.go.jp