The case of a male patient suffering from chronic normal pressure hydrocephalus is outlined. Antidepressant and pravastatin were administered because of the patient's abulia and hypercholesterolemia, but neuroleptic malignant syndrome-like conditions developed. All physicians should suppose the occurrence of such an "unexpected drug-interaction" in any case. The author considered that a good sense of careful discernment and rapid reference system of medical information are "essential tools" for clinical management.
[Rinsho Byori 50 : 133～139, 2002]
*Clinical Laboratory, Saga Medical School Hospital, Saga 849-8501
【Key Words】drug interaction(薬剤相互作用)，neuroleptic malignant syndrome(悪性症候群)，pravastatin(プラバスタチン)，antidepressant(抗鬱薬)，organic brain damage(器質性脳障害)
*佐賀医科大学附属病院検査部(〒849-8501佐賀市鍋島5-1-1)