The case of a male patient suffering from chronic normal pressure hydrocephalus is outlined. Antidepressant and pravastatin were administered because of the patient's abulia and hypercholesterolemia, but neuroleptic malignant syndrome-like conditions developed. All physicians should suppose the occurrence of such an "unexpected drug-interaction" in any case. The author considered that a good sense of careful discernment and rapid reference system of medical information are "essential tools" for clinical management.

*Clinical Laboratory, Saga Medical School Hospital, Saga 849-8501

【Key Words】drug interaction, neuroleptic malignant syndrome, pravastatin, antidepressant, organic brain damage