薬物相互作用(2)

解熱剤投与後のインフルエンザ脳症重症化と
CYP2C9 多型との関連性について

舩　渡　忠　男*1　小　澤　鹿　子*2　賀　来　満　夫*3
　　　　　　　　　　　　　　　　　　　　　　
Relationship of Polymorphism in CYP2C9 to Genetic Susceptibility to
Diclofenac-Induced Influenza-Virus-Associated Encephalopathy

Tadao FUNATO, MD*1, Kanoko KOZAWA*2 and Mitsuo KAKU, MD*3

The mechanism causing influenza-virus-associated encephalopathy is unclear, even though diclofenac metabolites may induce this pathogenesis. CYP2C9 is known as the major cytochrome P450 gene product that catalyzes diclofenac in human liver. It is uncertain whether the mutation of CYP2C9 is associated the pharmacologic effects of diclofenac in influenza infection. Therefore, we applied a simple and rapid procedure involving real-time fluorescence allele-specific PCR(TaqMan-ASA) assay and denaturing HPLC assay to detect the mutation of CYP2C9 gene. A single-base mutation in the CYP2C9 gene was found in one of thirty subjects in the healthy population. We suggest that this mutation in the CYP2C9 gene may be related to diclofenac-induced influenza-virus-associated encephalopathy.
[Rinsho Byori 50 : 140〜145, 2002]

*1Division of Molecular Diagnostics, Department of Clinical Medicine, Tohoku University, School of Medicine, Sendai 980-8574

【Key Words】influenza-virus-associated encephalopathy(インフルエンザ脳症)，diclofenac(ジクロフェナク)，CYP2C9 polymorphism(多型性)，single nucleotide polymorphisms：SNPs(一塩基多型)

*1〜3東北大学大学院医学系研究科病態制御学講座分子診断学分野(〒980-8574仙台市青葉区星陵町1-1)

E-mail :tfunato@mail.cc.tohoku.ac.jp