総　　　説

タングストリン酸によるメチシリン耐性黄色ブドウ球菌
(MRSA)のβ-ラクタム剤に対する感受性化効果

田　島　　　裕*
　　　　　　　　　　　　　　　　　　　　　　
Undecatungstophosphate Sensitized Strains of
Methicillin-Resistant Staphylococcus aureus to β-Lactams

Yutaka TAJIMA, MD*

Previously, a factor(Factor T) was found in aged mixtures of tungstate and phosphate, which greatly sensitizes strains of methicillin-resistant Staphylococcus aureus to β-lactams. Factor T was purified and identified as undecatungstophosphate([PW₁₁O₃₉]⁷⁻). Undecatungstosilicate([SiW₁₁O₃₉]⁸⁻), a compound closely related to undecatungstophosphate, showed a similar enhancing effect. Chemically, these compounds are classified as " polyoxotungstates ", and it is expected that these tungsten compounds will be useful as a " tool " in laboratory tests : i.e., in screening media for highly resistant MRSA strains. They may be also useful to investigate the resistant mechanism of the bacterial cells.
[Rinsho Byori 50 : 173〜185, 2002]

*Clinical Laboratory, Saga Medical School Hospital, Saga 849-8501

【Key Words】methicillin-resistant Staphylococcus aureus：MRSA(メチシリン耐性黄色ブドウ球菌)，β-lactam antibiotics(β-ラクタム剤)，undecatungstophosphate([ウンデカ]タングストリン酸)

受付2001年6月28日・受理2001年11月15日
*佐賀医科大学附属病院検査部(〒849-8501 佐賀市鍋島5-1-1)