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[Rinsho Byori 50 : 173-185, 2002]
Undecatungstophosphate Sensitized Strains of Previously, a factor(Factor T) was found in aged mixtures of tungstate and phosphate, which greatly sensitizes strains of methicillin-resistant Staphylococcus aureus to Ą-lactams. Factor T was purified and identified as undecatungstophosphate([PW11O39]7|). Undecatungstosilicate([SiW11O39]8|), a compound closely related to undecatungstophosphate, showed a similar enhancing effect. Chemically, these compounds are classified as " polyoxotungstates ", and it is expected that these tungsten compounds will be useful as a " tool " in laboratory tests : i.e., in screening media for highly resistant MRSA strains. They may be also useful to investigate the resistant mechanism of the bacterial cells.
*Clinical Laboratory, Saga Medical School Hospital, Saga 849-8501 |