器質的心疾患症例における T-wave alternans，
QT c dispersion，および late potential による
VT 予測の比較検討

大　久　典　子*1　大　平　未　佳*2　溝　述　克　実*3
船　渡　忠　男*4　賀　来　満　夫*5　宗　像　靖　彦*6
　　　　　　　　　　　　　　　　　　　　　　
Comparative Study of T-Wave Alternans, QT c Dispersion and Late Potential for
Predicting Ventricular Tachycardia in Patients with Ischemic Heart Disease

Noriko OHISA*1, Mika OHIRA*2, Katsumi MIZONOBE*3,
Tadao FUNATO, MD*4, Mitsuo KAKU, MD*5 and Yasuhiko MUNAKATA, MD*6

Ventricular tachycardia(VT) is well known as the life-threatening arrhythmia. It would be important for predicting the risk of VT to prevent sudden death caused by VT after myocardial damage such as old myocardial infarction and dilated cardiomyopathy. In this study, we examined late potential(LP), TWA alternans(TWA), and QTc dispersion(QTcd) measured by Holter ECG, in 21 patients with old myocardial infarction(OMI) and 21 patients with dilated cardiomyopathy(DCM), and evaluated these parameters in relation with the occurrence of VT on these patients. The sensitivities of LP, TWA, and QTcd in patients with OMI in relation with VT were 82%, 73%, and 82%, respectively, and those in patients with DCM were 82%, 93%, and 73%, respectively. The specificities of LP, TWA, and QTcd in patients with OMI in relation with VT were 100%, 40%, and 100%, respectively, and those in patients with DCM were 100%, 30%, and 100%, respectively. The data demonstrated that LP and TWA were the useful predictive parameters for the VT on myocardial damage such as OMI and DCM.
[Rinsho Byori 50 : 191〜195, 2002]

*1Department of Clinical Laboratory, Tohoku University Hospital, Sendai 980-8574

【Key Words】T-wave alternans：TWA，QTc dispersion：QTcd，late potential：LP(心室遅延電位)，ven-tricular tachycardia：VT(心室頻拍)，ischemic heart disease：IHD(虚血性心疾患)

受付2001年7月2日・受理2001年11月15日
*1〜3東北大学医学部附属病院検査部，*4〜6同　医学部分子診断学(〒980-8574 仙台市青葉区星陵町1)

E-mail :bigkyu-thk@umin.ac.jp