高脂血症の現状と検査(5)

酸化変性 LDL の臨床的意義と測定法

岡　田　正　彦*
　　　　　　　　　　　　　　　　　　　　　　
Oxidized LDL, Clinical Aspects and Measurement Methods

Masahiko OKADA, MD*

It is well recognized that oxidative modification of low-density lipoprotein(LDL) accelerates atherogenesis of the arterial vascular wall. Each of lipid peroxidation products, surface charge, or spectrophotometric patterns is applicable to the evaluation of in vitro oxidation. The lag time may contribute to the evaluation of effect of the lipid lowering and antioxidant drugs. ELISA using monoclonal antibody has the potential for clinical use. However, the applicability is not yet established, because of the different kinds of antibody used.
[Rinsho Byori 50 : 248〜253, 2002 ]

*Division of Clinical Preventive Medicine, Niigata University Graduate School of Medical and Dental Science, Niigata 951-8510

【Key Words】oxidized LDL(酸化 LDL)，lipid peroxidation(過酸化脂質)，surface charge(表面荷電)，conjugated dienes(酸化共役物)，autoantibody against oxidized LDL(抗酸化 LDL 自己抗体)

*新潟大学大学院医歯学総合研究科予防医療学分野(〒951-8510 新潟市旭町通1-757)

E-mail :okadar@med.niigata-u.ac.jp