Review

造血器腫瘍の遺伝子診断

奈　良　信　雄*
　　　　　　　　　　　　　　　　　　　　　　
Molecular Diagnosis in Hematologic Malignancies

Nobuo NARA, MD*

Recent advances in molecular diagnosis in the hematological laboratory have greatly contributed to the diagnosis and treatment of hematologic malignancies, such as leukemia and lymphoma. The pathogenesis of leukemia and lymphoma has been disclosed by the analyses of genetic abnormalities in patients ; abnormal gene expression may induce derangement in the control of cellular proliferation. Based on these genetic abnormalities, gene-targeted therapy has been introduced as a new approach to treating hematologic malignancies. We discuss here the usefulness of the molecular diagnosis in clinical hematology.
[Rinsho Byori 50 : 331〜336, 2002]

*Laboratory Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519

【Key Words】molecular diagnosis(遺伝子診断)，leukemia(白血病)，gene-targeted therapy(遺伝子標的治療)，BCR，BCR/ABL-specific kinase inhibitor STI571(BCR/ABL 特異的キナーゼ阻害薬 STI571)，ATRA

　*東京医科歯科大学大学院医歯学総合研究科臨床検査医学分野(〒113-8519 東京都文京区湯島1-5-45)
　本論文は第48回日本臨床検査医学会総会 教育講演 4をReviewとして掲載した。