The homeostasis model assessment-insulin resistance(HOMA-IR) index has
been proposed to assess insulin resistance, which plays an important role
in the pathogenesis of type 2 diabetes mellitus. However, it has not generally
introduced into the outpatient care in Japan, because of lack in definite
reference values. In this paper we studied the precision in the assay of
immuno-reactive insulin and then the HOMA-IR index was determined in 90
healthy individuals and 281 type 2 diabetic patients. The reference value
was calculated to be 1.77±0.44(mean±SD) in healthy individuals without
obesity. Receiver operating characteristic curve analysis gave the cut-off
values discriminating between healthy and diabetic subjects to be 2.53,
3.50 and 3.00 in non-obese, obese and total individuals, respectively.
These values should be available for the diagnosis of insulin resistance
in type 2 diabetes mellitus.
[Rinsho Byori 50 : 398～403, 2002]
*1Kotobiken Medical Laboratories, Inc., Tsukuba 305-0854
【Key Words】type 2 diabetes mellitus(2 型糖尿病)，insulin resistance(インスリン抵抗性)，HOMA-IR，reference value(基準値)，cut-off value(カットオフ値)
受付2001年10月13日・受理2002年1月18日
*1㈱江東微生物研究所(〒305-0854 つくば市上横場445-1)
*2,3つくば糖尿病センター川井クリニック(〒305-0812 つくば市東平塚715-1)
E-mail :kuwana@lily.ocn.ne.jp