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[Rinsho Byori 50 : 502～505, 2002]
Increase of Soluble FcγRIIIa Derived from Macrophages in Plasma Macrophages play a major role in the development of vascular lesions in
atherogenesis. The cells express FcγRIIIa(CD16) identical to that in NK
cells, but with a cell type-specific glycosylation. In contrast, neutrophils
express FcγRIIIb in two allotypes, NA1- and NA2- Fc γRIIIb. These FcγRIIIs
are released from the cell surface on activation, and these soluble forms(sFcγRIII)
are present in plasma. In the present study, we measured sFcγRIIIaMφ in plasma with Immuno-PCR with newly-developed anti-FcγRIII mAb, MKGR14(mIgM),
which recognizes FcγRIIIaMφ specifically. In healthy donors, the level of sFcγRIIIaMφ increased with age. In contrast, the sFcγRIIIa level correlated with
the number of NK cells in peripheral blood, and the level of total sFcγRIII(sFcγRIIIa
plus sFcγRIIIb) correlated with the number of neutrophils. There was no
correlation among the levels of three sFcγRIIIs was observed in healthy
donors. The levels of these sFcγRIII were significantly increased in patients
with coronary artery disease(CAD) compared with age-matched healthy donors.
The sFcγRIIIaMφ level was related to the number of significant coronary artery stenoses,
and correlated with the sFcγRIIIa level, total cholesterol, HDL-cholesterol(negatively),
LDL to HDL ratio, triglycerides and body mass index. These findings may
show that the macrophages are activated during the incipient stage of atherosclerosis,
and that sFcγRIIIaMφ may serve as predictive marker for atherosclerosis. |