Drug discovery is a continuum of the processes, i.e. identification of disease-associated targets, screening of compound libraries, identification of leads and their optimization to drugs, preclinical and clinical drug development. Recent advances in genomic sciences will greatly reinforce processes such as early target identification and clinical researches. Particularly, exploitation of genomic information in clinical researches is expected to revolutionarily improve drug development and eventual clinical use. Ultimately, tailor-made medicine will provide us with great benefit in the near future therapy.
[Rinsho Byori 50 : 694～697, 2002]
*Tsukuba Research Laboratories, GlaxoSmithKline K.K., Tsukuba 300-4247
【Key Words】genomic drug discovery(ゲノム創薬)，pharmacogenetics(薬理遺伝学)，tailor-made medicine(テーラーメイド医療)，disease-susceptibility gene(疾患感受性遺伝子)，single nucleotide polymorphism：SNP(一塩基多型)
*グラクソ・スミスクライン㈱生物科学研究部(〒300-4247 つくば市和台43)