Drug discovery is a continuum of the processes, i.e. identification of disease-associated targets, screening of compound libraries, identification of leads and their optimization to drugs, preclinical and clinical drug development. Recent advances in genomic sciences will greatly reinforce processes such as early target identification and clinical researches. Particularly, exploitation of genomic information in clinical researches is expected to revolutionarily improve drug development and eventual clinical use. Ultimately, tailor-made medicine will provide us with great benefit in the near future therapy.


*Tsukuba Research Laboratories, GlaxoSmithKline K.K., Tsukuba 300-4247

【Key Words】genomic drug discovery, pharmacogenetics, tailor-made medicine, disease-susceptibility gene, single nucleotide polymorphism:SNP