最近の血液検査(5)

血小板の活性化とその検出法

佐　藤　金　夫*1　矢　冨　　　裕*2　尾　崎　由基男*3
　　　　　　　　　　　　　　　　　　　　　　
Detection Method for Platelet Activation Markers

Kaneo SATOH*1, Yutaka YATOMI, MD*2,
and Yukio OZAKI, MD*3

The assessment of platelet activation levels may be useful for identifying patients who would benefit from antiplatelet therapy and prediction of ischemic events. Laboratory markers of platelet activation include activation-dependent changes in glycoprotein(GP) IIb/IIIa complex, exposure of granule membrane proteins, binding of secreted platelet proteins, and development of procoagulant surfaces. Whole blood flow cytometry is a popular and useful method for the detection of these markers of platelet activation. Monoclonal antibodies against platelet surface glycoproteins are used to identify activated platelets.
[Rinsho Byori 50 : 773〜778, 2002]

*1Department of Laboratory Medicine, Yamanashi Medical University, Yamanashi-pref. 409-3898

【Key Words】platelet activation marker(血小板活性化マーカー)，CD62P，PAC 1，platelet-derived microparticle(血小板由来マイクロパーティクル)，annexin V(アネキシン V)

*1〜3山梨医科大学臨床検査医学(〒409-3898 山梨県中巨摩郡玉穂町下河東1110)

E-mail :ksatoh@res.yamanashi-med.ac.jp