The assessment of platelet activation levels may be useful for identifying patients who would benefit from antiplatelet therapy and prediction of ischemic events. Laboratory markers of platelet activation include activation-dependent changes in glycoprotein(GP) IIb/IIIa complex, exposure of granule membrane proteins, binding of secreted platelet proteins, and development of procoagulant surfaces. Whole blood flow cytometry is a popular and useful method for the detection of these markers of platelet activation. Monoclonal antibodies against platelet surface glycoproteins are used to identify activated platelets.

*1Department of Laboratory Medicine, Yamanashi Medical University, Yamanashi-pref. 409-3898

【Key Words】platelet activation marker, CD62P, PAC 1, platelet-derived microparticle, annexin V