The mechanism involved in the formation of arteriosclerosis is complicated
and not fully understood. To define the mechanism, studies have been performed
in various fields ; lipid metabolism and the coagulation system in serum,
cell biological and pathological research in the arterial wall. This symposium
will present two papers from basic research and four from clinical research.
Basic research papers showed the relationship between cytokines and the
formation of atherosclerosis and showed the possibility that markers of
thrombus formation may be available in the future, thereby facilitating
early treatment for thrombosis. Clinical research papers have shown that
gene variant of homocystein showed a high homocystein level in serum and
is strongly associated with the incidence of FCHL, ischemic heart disease
and the progression of arteriosclerosis in patients on hemodialysis. Thus,
reducing the homocystein level may prevent the progression of arteriosclerosis.
Lastly, the intermittent gait test is necessary to evaluate the degree
of arteriosclerosis in patients with ASO.
[Rinsho Byori 50 : 791〜792, 2002]
*1Department of Laboratory Medicine, Gifu University School of Medicine, Gifu 500-8705
*2Department of Clinical Laboratory, National Kanazawa Hospital, Kanazawa 920-8650
*1岐阜大学医学部臨床検査医学講座(〒500-8705 岐阜市司町40)
*2国立金沢病院臨床検査科(〒920-8650 金沢市下石引町1-1)
E-mail :seishima@cc.gifu-u.ac.jp