原　　　著

高感度エストラジオール測定キットを用いた
神経性食欲不振症における性腺機能の検討

地　曵　和　子*1　堀　田　眞　理*2　岡　地　理　恵*3
小田桐　恵　美*4　高　野　加寿恵*5　　　　　　　　
　　　　　　　　　　　　　　　　　　　　　　
Studies on the Gonadal Function in Patients with Anorexia Nervosa
Using a Highly Sensitive Radioimmunoassay Kit for Estradiol

Kazuko JIBIKI*1, Mari HOTTA, MD*2, Rie OKAJI*3,
Emi ODAGIRI, MD*4 and Kazue TAKANO, MD*5

We measured serum estradiol(E2) using a highly sensitive radioimmunoassay kit in patients with anorexia nervosa(AN). It is possible to determine the ovarian function with hypogonadism in patients with AN whose levels of E2 were below 10pg/ml. In patients with extremely low levels of BMI(less than 15kg/m2), basal levels of E2, LH, FSH and IGF-I increased significantly with gain of body weight.
Recovery of the hypothalamic-pituitary-ovarian function in AN patients were correlated with weight gain and nutritional status. The levels of IGF-I and E2 raised in advance of gonadotropins.
Using highly sensitive assay of E2, we recognized the clinical usefulness for evaluation of the ovarian function in patients with AN in the course of treatment.
[Rinsho Byori 50 : 824〜829, 2002]

*1Central Clinical Laboratories, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 162-8666

【Key Words】High sensitive radioimmunoassay kit for E2(E2 測定用高感度ラジオイムノアッセイキット)，BMI(肥満指数)，LH，FSH，IGF-I

受付2002年4月30日・受理2002年7月11日
*1,3,4東京女子医科大学病院中央検査部，*2,5同　内分泌疾患総合医療センター内科(〒162-8666 新宿区河田町8-1)

E-mail :jibiki@clabo.zengaku.twmu.ac.jp