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[Rinsho Byori 50 : 824`829, 2002]
Studies on the Gonadal Function in Patients with Anorexia Nervosa
Using a Highly Sensitive Radioimmunoassay Kit for Estradiol
Kazuko JIBIKI*1, Mari HOTTA, MD*2, Rie OKAJI*3,
Emi ODAGIRI, MD*4 and Kazue TAKANO, MD*5
We measured serum estradiol(E2) using a highly sensitive radioimmunoassay kit in patients with anorexia nervosa(AN). It is possible to determine the ovarian function with hypogonadism in patients with AN whose levels of E2 were below 10pg/ml. In patients with extremely low levels of BMI(less than 15kg/m2), basal levels of E2, LH, FSH and IGF-I increased significantly with gain of body weight.
Recovery of the hypothalamic-pituitary-ovarian function in AN patients were correlated with weight gain and nutritional status. The levels of IGF-I and E2 raised in advance of gonadotropins.
Using highly sensitive assay of E2, we recognized the clinical usefulness for evaluation of the ovarian function in patients with AN in the course of treatment.
*1Central Clinical Laboratories, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 162-8666
yKey WordszHigh sensitive radioimmunoassay kit for E2, BMI, LH, FSH, IGF-I
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