ヒト Germline 遺伝子検査の現状と今後の課題(2)

2 型糖尿病の遺伝子多型の診断

三　家　登喜夫*
　　　　　　　　　　　　　　　　　　　　　　
Diagnostic Use of Gene Polymorphism for Type 2 Diabetes

Tokio SANKE, DM*

Type 2 diabetes is thought be a multifactorial disease and both genetic and acquired factors contribute its pathogenesis. Elucidation of susceptibility genes for type 2 diabetes thus leads to primary prevention for the disease. Although main susceptibility genes for type 2 diabetes have not been found, I present our data using candidate gene approach. Our data include the amylin gene S20G and the Pax4 gene R121W mutations and also include the muscle glycogen synthase gene M416V polymorphism that correlates to insulin resistance as a thrifty gene.
[Rinsho Byori 50 : 871〜876, 2002]

*Department of Clinical Laboratory Medicine, Wakayama Medical University, Wakayama 641-8509

【Key Words】type 2 diabetes(2型糖尿病)，gene polymorphism(遺伝子多型)，amylin(アミリン)，transcription factor(転写因子)，thrifty gene(倹約遺伝子)

*和歌山県立医科大学臨床検査医学(〒641-8509 和歌山市紀三井寺811-1)

E-mail :sanke-t@wakayama-med.ac.jp