A patient consulted the emergency room with acute pancreatitis, hypertriglyceridemia,
and diabetes mellitus, and was later admitted to the hospital. Serum levels
of total cholesterol(TC) and total triglyceride(TTG), and the cholesterol(Chol)
versus triglyceride(TG) ratio(Chol/TG) for lipoprotein fractions were examined
periodically during the course of treatment using Chol/Trig Combo®,
which identifies Chol and TG by differential staining.
On admission, the patient's TTG, pancreatic amylase and glucose levels were 4020mg/dl, 2012 IU/l, and 242mg/dl, respectively.
Clinofibrate administration resulted in a decrease in Chol and TG values for all fractions. However, the Chol/TG ratios were unchanged(HDL of 0.2 to 0.4, VLDL of approximately 0.13, and LDL of 0.1 to 0.2 : Reference values from 103 healthy students were as follows : HDL 5.8±2.0, VLDL 0.39±0.1, and LDL 4.9±1.3[Mean±SD].).
During clinofibrate treatment, TC and TG values gradually increased. Clinofibrate was discontinued and fenofibrate administration was initiated. This was followed by a dramatic improvement in TC, TTG and Chol/TG values for both HDL and LDL. The monitoring of lipoprotein fraction values proved useful for determining the treatment regimen for this patient with hypertriglyceridemia.
[Rinsho Byori 50 : 987〜991, 2002]
*1Clinical Laboratories, Kobe University Hospital, Kobe 650-0017
【Key Words】hypertriglyceridemia(高トリグリセライド血症)，composition
of lipoprotein(リポ蛋白の組成)，the cholesterol versus triglyceride ratio
for lipoprotein fractions(リポ蛋白分画中のコレステロールとトリグリセライドの比)，Chol/Trig
Combo®(コレトリコンボ®)
受付2001年12月17日・受理2002年9月20日
*1〜5神戸大学医学部附属病院中央検査部，*6同 大学院医学系研究科応用分子医学(糖尿病・消化器・腎臓内科学)，
*7同 大学院医学系研究科医学生体情報医学(臨床病態・免疫学)(〒650-0017 神戸市中央区楠町7-5-2)
E-mail :itsuko@med.kobe-u.ac.jp