Transplantation has become a standard therapy offering potential cures
for a numbers of disorders. Patients undergoing transplantation are exposed
to the risk of developing bacterial, viral and fungal infections due to
underlying diseases, transplantation protocols, and treatment regimens.
Severe infections are a major course of morbidity and mortality. Early
diagnosis is essential for the prompt initiation of appropriate therapy
and the management of such complications.
Posttransplant microbiological surveillance is used for identifying patients
at high risk and when infection is suspected. Microbiological examinations
are also performed in some instances to monitor the patient's response
to therapy. Molecular detection of microorganisms is a rapid diagnostic
technique and becomes a useful tool for early recognition and treatment
of viral and fungal infections.
[Rinsho Byori 50 : 1055～1060, 2002]
*Division of Molecular Diagnostics, Department of Clinical Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8574
【key words】posttransplant infection(移植後感染症)，opportunistic infection(日和見感染症)，rapid
diagnosis(迅速診断)，noninvasive diagnosis(非侵襲的診断)，nucleic acid
amplification technique(核酸増幅技術)
*東北大学大学院医学系研究科病態制御学講座分子診断学分野(〒980-8574 仙台市青葉区星陵町1-1)
E-mail :ishii-k@mail.cc.tohoku.ac.jp