教育講演

肺傷害と血清マーカー

諏訪部　　　章*
　　　　　　　　　　　　　　　　　　　　　　
Lung Injury and Serum Markers

Akira SUWABE, MD*

The lung injury such as interstitial pneumonia and pulmonary fibrosis causes severe respiratory failure resulting in poor prognosis. Recently, SP-A and SP-D as well as KL-6 are known as serum markers for these lung injuries. SP-A and SP-D are the surfactant specific proteins and synthesized by alveolar type II epithelial cells. KL-6 is one of the membrane proteins of type II cells. As these proteins are highly specific to the lungs, they are used as serum markers for diagnosis, determination of the severity, follow up of the clinical course and prognosis of interstitial pneumonia. Although these markers are clinically useful, further information on the mechanisms why they are present in the serum and also on the relationships between these proteins needs to be accumulated.
[Rinsho Byori 50 : 1061〜1066, 2002 ]

*Department of Laboratory Medicine, School of Medicine, Iwate Medical University, Morioka 020-8505

【Key Words】lung injury(肺傷害)，serum marker(血清マーカー)，SP-A，SP-D，KL-6

*岩手医科大学医学部臨床検査医学(〒020-8505 盛岡市内丸19-1)

E-mail :asuwabe@iwate-med.ac.jp