IgA 沈着優位の Immunotactoid glomerulopathy における
糸球体沈着物内構造物の免疫電顕による検討
川 島 真由子*1 堀 田 茂*2 中 山 英 喜*3 本 田 一 穂*4
内 田 啓 子*5 新 田 孝 作*6 湯 村 和 子*7 二 瓶 宏*8
Immunoelectron Microscopic Analysis of Intraglomerular Deposits
in IgA-Dominant Immunotactoid Glomerulopathy
Mayuko KAWASHIMA*1, Shigeru HORITA*2, Hideki NAKAYAMA*3, Kazuho HONDA*4,
Keiko UCHIDA*5, Kosaku NITTA*6, Wako YUMURA*7 and Hiroshi NIHEI*8
Immunotactoid glomerulopathy(ITG) demonstrates glomerular deposits that
are characterized by highly organized ultrastructure. The deposits appear
to be composed of immunoglobulin and complement that were negative for
amyloid by Congo red stain. However, it has been difficult to distinguish
the difference between ITG and fibrillary glomerulonephritis. In the present
study, we performed an immunoelectron microscopic study to identify the
factors that seemed to be associated with the glomerular deposits in a
case of IgA-dominant ITG. IgA, light chain k and fibrinogen were colocalized
in association with fibrillar deposits in the extracellular matrix of mesangial
cells. Therefore, it is likely that the complex of IgA, light chain k and
fibrinogen are associated with the formation of highly organized ultrastructural
deposits in a case of IgA-dominant ITG.
[Rinsho Byori 50 : 1085〜1089, 2002]
*1Tokyo Women's Medical University, Kidney Center, Shinjuku-ku, Tokyo 162-8666
【Key Words】Immunotactoid glomerulopathy，免疫電顕，糸球体内細線維様構造物，IgA，κ鎖
受付2002年8月5日・受理2002年10月23日
*1〜3東京女子医科大学腎臓病総合医療センター病理検査室，*4同 第二病理，*5〜8同 第四内科
(〒162-8666 東京都新宿区河田町8-1)
E-mail :mkawa@kc.twmu.ac.jp