RA 患者における MMP-3 の測定意義
−他指標(IL-6，IL-8)との比較から−
浜 川 英 嗣*1 竹 村 正 男*2 佐 藤 正 夫*3 四 戸 隆 基*4
小 石 浩 久*5 古 田 伸 行*6 太 田 浩 敏*7 小 池 紀 子*8
岩 本 直 樹*9 山 田 泰 弘*10 和 田 久 泰*11 斎 藤 邦 明*12
清 島 満*13
Clinical Significance of MMP-3 in Patients with Rheumatoid Arthritis
：Comparison with other Inflammatory Markers(IL-6, IL-8)
Hidetsugu HAMAKAWA*1, Masao TAKEMURA*2, Masao SATO*3, Ryuki SHINOHE*4,
Hirohisa KOISHI*5, Nobuyuki FURUTA*6, Hirotoshi OHTA*7,
Noriko KOIKE*8, Naoki IWAMOTO*9, Yasuhiro YAMADA*10,
Hisayasu WADA*11, Kuniaki SAITO*12 and Mitsuru SEISHIMA*13
We determined serum metalloproteinase-3(MMP-3) and inflammatory cytokine(IL-6, IL-8) levels in patients with rheumatoid arthritis(RA).
Sera were obtained from 307 healthy subjects(female 140, male 167), 54 RA patients, and 17 osteoarthritis(OA). The MMP-3 concentrations in healthy female and male were 43.3±15.3ng/ml and 90.7±26.0ng/ml, respectively. The serum MMP-3 levels in male were significantly higher than those in female (p＜0.0001). MMP-3 levels in RA patients(259.1±34.2ng/ml) were significantly higher than OA(43.6±6.1ng/ml) or healthy controls. There was a significant correlation between MMP-3 and CRP(r＝0.586), IL-6(r＝0.345) levels in serum. In contrast, no significant correlation was observed between MMP-3 and IL-8(r＝0.19), or CA-RF(r＝0.052) levels. However, there were some cases with high MMP-3 levels in CA-RF-negative patients definitely diagnosed as RA. These findings suggest that MMP-3 determination is useful for the early diagnosis and the follow-up during the treatment for RA patients.
[Rinsho Byori 51 : 13〜18, 2003]
*1Department of Clinical Laboratory Medicine, Gifu University School of Medicine, Gifu 500-8705
【Key Words】rheumatoid arthritis：RA(関節リウマチ)，MMP-3(マトリックスメタロプロテアーゼ-3)，CA-RF(抗ガラクトース欠損リウマチ因子)，IL-6(インターロイキン 6)，IL-8(インターロイキン 8)
受付2002年8月22日・受理2002年12月20日
*1,10〜13岐阜大学医学部臨床検査医学講座，*2,6〜8同 附属病院検査部(〒500-8705
岐阜市司町40)
*3〜5総合大雄会病院 整形外科(〒491-8551 一宮市桜1-9-9)
*9一宮女子短期大学 食物栄養学科(〒491-0938 一宮市日光町6)