Oxidative stress is known to be related to various diseases such as inflammation,
carcinogenesis, arteriosclerosis and ischemia-reperfusion injury, and is
also a major cause of aging. For the prevention of diseases and control
of aging, evaluation and control of oxidative stress in vivo may become
essential. We have developed the new Oxidative Stress Profile(OSP), a total
diagnostic system which provides information about oxidative stress inside
human body. The OSP system consists of a number of biomarkers including
oxidative damage markers, prooxidant factors, antioxidants and life style-related
markers. The result is shown in a two dimensional plot form. We measured
a combination of biomarkers for oxidative damage of biological components,
serum antioxidants and analyzed oxidative stress. The result show that
oxidative stress was elevated in diabetic patients in comparison with normal
controls. Oxidative stress is also elevated in smokers in comparison with
non-smokers. It is also interesting to find that oxidative stress can be
greatly reduced by the improvement of life style such as diet. Oxidative
Stress Profile system may become a powerful tool for the evaluation of
oxidative stress in vivo, and may be useful in prevention of diseases,
"mi-byo"(possible cause of diseases)-diagnosis and the control
of aging.
[Rinsho Byori 51 : 115〜125, 2003]
*1,2Japan Institute for the Control of Aging, Fukuroi 437-0122
【Key Words】oxidative stress biomarker(酸化ストレスバイオマーカー)，8-hydroxy-deoxyguanosine：8-OHdG，oxidative stress profile：OSP，oxidative stress status index：OSSI，oxidative stress prevention potential index：OSPPI，"mi-byo"-diagnosis(未病診断)
*1,2日本老化制御研究所(〒437-0122 袋井市春岡723-1)
E-mail :biotech@jaica.com