癌・感染症の遺伝子診断(4)

薬物代謝酵素遺伝子多型と
抗癌剤の薬効・副作用

小　澤　正　吾*
　　　　　　　　　　　　　　　　　　　　　　
Genetic Polymorphisms on Drug Metabolizing Enzymes
in Relation to Anti-Cancer Drug Effectiveness

Shogo OZAWA*

Wide inter-individual difference has been documented for various drug metabolizing enzymes(DMEs) and drug transporters. Some of the single nucleotide polymorphisms(SNPs) existing in the genes encoding DMEs and drug transporters have been associated with the deficiency of DMEs and the transporters. In the case of therapeutic drugs that undergo metabolism by a single DME, serious adverse effect might occur for patients who are devoid of the DME. Function of a number of DMEs and transporters are likely to affect drug effectiveness of three anti-cancer agents, irinotecan, taxol and 5-fluorouracil. Genetic polymorphisms of the genes related to the effectiveness of these drugs are discussed from the aspect of effects of the genetic polymorphisms on their metabolism and disposition.
[Rinsho Byori 51 : 168〜173, 2003]

*Division of Pharmacology, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501

【Key Words】drug-metabolizing enzymes(薬物代謝酵素)，drug transporters(薬物トランスポーター)，genetic polymorphisms(遺伝子多型)，anti-cancer drugs(抗癌剤)，drug responsiveness(薬物応答性)

*国立医薬品食品衛生研究所・薬理部(〒158-8501 東京都世田谷区上用賀1-18-1)

E-mail :sozawa@nihs.go.jp