抗 DNA 抗体に関する一仮説
田 島 裕*
A Hypothesis about Anti-DNA Antibody
Yutaka TAJIMA, MD*
“Anti-DNA antibody” is the antibody which can bind DNA molecules. It is well accepted that this antibody, especially in anti-double strand DNA antibody, has a high disease specificity for SLE. Usually, the antibody is detected by using DNA molecule as a binding target in the clinical laboratory test performed in vitro. However, it is quite unknown what the antibody is actually attacking in vivo. This review will introduce many findings known to date and try to solve the mystery of anti-DNA antibody with a hypothesis that the antibody nonspecifically crossreacts to negatively charged substances(e. g., polysaccharides) in vivo. Probably, a type of charge interaction is dominantly involved in this binding.
[Rinsho Byori 51 : 615〜626, 2003]
*Clinical Laboratory, Saga Medical School Hospital, Saga 849-8501
【Key Words】anti-DNA antibody(抗 DNA 抗体)，systematic lupus erythematosus：SLE(全身性エリテマトーデス)，cross reactivity(交差反応)，charge interaction(荷電相互作用)，polysaccharide(多糖類)
受付2002年6月10日・受理2003年5月14日
*佐賀医科大学附属病院検査部(〒849-8501 佐賀市鍋島5-1-1)
E-mail :tajima@post.saga-med.ac.jp