最新自己抗体検査(2)

抗リン脂質抗体

鏑　木　淳　一*1　桑　名　正　隆*2　池　田　康　夫*3
　　　　　　　　　　　　　　　　　　　　　　
Antiphospholipid Antibodies

Junichi KABURAKI, MD, PhD*1, Masataka KUWANA, MD, PhD*2 and Yasuo IKEDA, MD, PhD*3

The concept of antiphospholipid syndrome(APS) has been widely accepted. Antiphospholipid antibodies originally included anticardiolipin antibodies and lupus anticoagulants as serological marker of APS. However, recent advances have shown that most pathogenic antiphospholipid antibodies are directed to phospholipid binding proteins such as β₂-glycoprotein I and prothrombin as well as phospholipids. The preliminary classification criteria for definite APS have been advocated as the “ Sapporo criteria”. Further prospective investigations are required to re-evaluate the clinical significance of so-called antiphospholipid antibodies.
[Rinsho Byori 51 : 639〜643, 2003]

*1Department of Internal Medicine, Tokyo Electric Power Company(TEPCO) Hospital, Shinjuku-ku, Tokyo 160-0016

【Key Words】thrombosis(血栓症)，fetal loss(子宮内胎児死亡)，anticardiolipin antibodies(抗カルジオリピン抗体)，β₂-GPI dependent anticardiolipin antibodies(β₂-GPI 依存性抗カルジオリピン抗体)

*1東京電力病院内科(〒160-0016 東京都新宿区信濃町9-2)
*2慶応義塾大学先端医科学，*3慶応義塾大学内科(〒160-8582 東京都新宿区信濃町35)

E-mail :kaburaki.j@tepco.co.jp