尿中変形赤血球の形態による
新たな出血源鑑別法の検討
三 浦 秀 人*1 五十嵐 雅 彦*2 富 永 真 琴*3
Evaluation of a New Method for Diagnosing the Origin of Urinary Bleeding
by the Morphological Characteristics of Urinary Red Blood Cells
Hideto MIURA*1, Masahiko IGARASHI*2 and Makoto TOMINAGA*3
In this study, we attempted to develop a new method for diagnosing the origin of urinary bleeding by the morphological characteristics of urinary red blood cells(RBC). Seventy-five samples were divided into five types by individual features using phase-contrast microscopy. It was revealed that the ratios of type III, namely acanthocytes, and IV, namely donut-shaped RBC, were significantly higher in patients with glomerular bleeding than those with non-glomerular bleeding. Acanthocytes seemed to be specific to glomerular bleeding, but some urinary samples from patients with glomerular bleeding did not show acanthocytes. Therefore, we suggest that the detection of a combination of acanthocytes and donut-shaped RBC in a urine sample is useful for the diagnosis of glomerular bleeding.
[Rinsho Byori 51 : 740～744, 2003]
*1Division of Clinical Laboratory, Yamagata University School of Medicine, Yamagata 990-9585
【Key Words】hematuria(血尿)，glomerulonephritis(糸球体腎炎)，glomerular bleeding(糸球体起原出血)，dysmorphic red blood cell(尿中変形赤血球)，acanthocyte(有棘赤血球)
受付2003年4月15日・受理2003年5月14日
*1山形大学医学部附属病院検査部，*2,3同 医学部臨床検査医学講座(〒990-9585 山形市飯田西2-2-2)
E-mail :hmiura@med.id.yamagata-u.ac.jp