[Rinsho Byori 51 : 740`744, 2003]

Evaluation of a New Method for Diagnosing the Origin of Urinary Bleeding
by the Morphological Characteristics of Urinary Red Blood Cells


Hideto MIURA*1, Masahiko IGARASHI*2 and Makoto TOMINAGA*3


In this study, we attempted to develop a new method for diagnosing the origin of urinary bleeding by the morphological characteristics of urinary red blood cells(RBC). Seventy-five samples were divided into five types by individual features using phase-contrast microscopy. It was revealed that the ratios of type III, namely acanthocytes, and IV, namely donut-shaped RBC, were significantly higher in patients with glomerular bleeding than those with non-glomerular bleeding. Acanthocytes seemed to be specific to glomerular bleeding, but some urinary samples from patients with glomerular bleeding did not show acanthocytes. Therefore, we suggest that the detection of a combination of acanthocytes and donut-shaped RBC in a urine sample is useful for the diagnosis of glomerular bleeding.

*1Division of Clinical Laboratory, Yamagata University School of Medicine, Yamagata 990-9585