慢性関節リウマチにおける血清中マトリックス
メタロプロテアーゼ-3(MMP-3)および抗ガラクトース
欠損 IgG 抗体(CA・RF)測定試薬の基礎的検討
浦 田 美秩代*1 中 村 信 子*2 木 下 幸 子*3
栢 森 裕 三*4 濱 﨑 直 孝*5
A Basic Study of Determination Matrix Metalloproteinase-3 and
Carbohydrate in Rheumatoid Factor in Serum for Diagnosis of Rheumatoid Arthritis
Michiyo URATA*1, Nobuko NAKAMURA*2, Sachiko KINOSHITA*3,
Yuzo KAYAMORI, PhD*4 and Naotaka HAMASAKI, MD, PhD*5
The examination of rheumatoid factor(RF), one of the diagnostic marker of rheumatoid arthritis(RA), showed negative about 25% of patients with RA. We analyzed a matrix metalloproteinase-3(MMP-3) and a carbohydrate in rheumatoid factor(CA・RF) for diagnosis of RA: the former is used the kit “Panaclear MMP-3｢Plate｣” and the latter is used the kit “Picolumi CA・RF”. The basic study of these reagents showed satisfactory results. In 73.3% of seronegative RA showed positive on both MMP-3 and CA・RF levels in serum, respectively. We found that these examinations might be useful for diagnosis of RA, especially during seronegative RA.
[Rinsho Byori 51 : 745～750, 2003]
*1Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka 812-8582
【Key Words】rheumatoid arthritis：RA(慢性関節リウマチ)，matrix metalloproteinase-3：MMP-3(マトリックスメタロプロテアーゼ-3)，carbohydrate in rheumatoid factor：CA・RF(抗ガラクトース欠損 IgG 抗体)，rheumatoid factor：RF(リウマトイド因子)
受付2003年5月26日・受理2003年6月24日
*1～5九州大学医学部附属病院検査部(〒812-8582 福岡市東区馬出3-1-1)
E-mail :urata@st.hosp.kyushu-u.ac.jp