遺伝子からみた生活習慣病としての高血圧症
梅 村 敏*
Genetic Aspect of Essential Hypertension
Satoshi UMEMURA, MD*
Essential hypertension affects up to 30% of the adult population; its pathogenesis involves interactions between genetic and environmental factors. Improved understanding of the molecular basis of essential hypertension may facilitate the development of new targeted forms of pharmacological therapy that can be tailored to the needs of individual patients and thereby minimize the risk of morbidity and mortality from cardiovascular diseases. The genetic analysis of complex traits and diseases such as blood pressure and hypertension is difficult because of their polygenic origin, genetic heterogeneity, variable penetrance, unknown modes of inheritance, and variable effects of environmental factors.
Molecular variants of the angiotensinogen(AGT) gene, a key component of the renin-angiotensin system, are considered a genetic risk for primary hypertension.
Some of the genotypes can be used to identify individual patients who would benefit from a specific antihypertensive treatment as well as from a specific life style modification.
[Rinsho Byori 51 : 813〜817, 2003]
*Department of Internal Medicine II, Yokohama City University, Yokohama 236-0004
【Key Words】essential hypertension(本態性高血圧症)，angiotensinogen(アンジオテンシノーゲン)，adducin(アデュシン)，single nucleotide polymorphisms：SNPs，b 3-adrenergic receptor(b 3 受容体)
*横浜市立大学医学部内科学第二講座(〒236-0004 横浜市金沢区福浦3-9)